Het wordt helaas niet volop toegepast,kijk maar naar het lijstje waar de dierenartsen op staan vermeld.
Maar ik heb mijn mening gegeven aan TS en jij die van jou dus aan haar wat te doen.
En wat betreft mijn eigen honden,ik doe niets klakkeloos.
Dit komt doordat het onderwerp niet meer recent is en in het hondenforum archief terecht ik gekomen.
Als je over "parvo?" wilt praten in het hondenforum dan kun je het beste een nieuw onderwerp aanmaken
Voor wie het interessant vindt. In antwoord op wel of niet op 8 weken vaccineren in plaats van 6 weken. Het advies wereldwijd luidt anders. Advies afgegeven en wetenschappelijk bestudeerd door een commissie van dierenartsen en wetenschappers die zich met de gezondheid van onze huisdieren bemoeien. Lees vooral de waarde van titerbepaling in het advies.
Quote:
Pup Vaccination and the 12 Month Booster
Most pups are protected by MDA in the first weeks of life. In general, passive immunity will have waned by 8–12 weeks of age to a level that allows active immunization. Pups with poor MDA may be vulnerable (and capable of responding to vaccination) at an earlier age, while others may possess MDA at such high titres that they are incapable of responding to vaccination until ?12 weeks of age. No single primary vaccination policy will therefore cover all possible situations. The recommendation of the VGG is for initial vaccination at 8–9 weeks of age followed by a second vaccination 3–4 weeks later, and a third vaccination given between
14–16 weeks of age. By contrast, at present many vaccine data sheets recommend an initial course of two injections.
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Serological Testing to Monitor Immunity to Canine Vaccines
Antibody tests are useful for monitoring immunity to CDV, CPV-2, CAV-1 and rabies virus.Antibody assays for CDV and CPV-2 are the tests of greatest benefit in monitoring immunity, especially after the puppy vaccination series. During recent years, many laboratories have standardized their methodologies for such testing. There are legal requirements for rabies antibody testing for pet travel between some countries.
In-practice testing will probably become more popular as soon as rapid, simple, reliable and cost-effective assays are more widely available.A negative test result indicates that the animal has little or no antibody, and that revaccination is recommended. Some of these dogs are in fact immune (false-negative), and their revaccination would be unnecessary. A positive test result on the other hand would lead to the conclusion that revaccination is not required. This is why robust yes/no answers must be provided by any assay. With CDV and/or CPV-2 tests, an animal with a negative result, regardless of the test used, should be considered as having no antibody and susceptible to infection.
On completion of the puppy series at 14–16 weeks of age, an animal should have a positive test result, provided the serum sample is collected 2 or more weeks after vaccination. Seronegative animals should be revaccinated and retested. If it again tests negative, it should be considered a non-responder that is possibly incapable of developing protective immunity.
Testing for antibody is presently the only practical way to ensure that a puppy’s immune system has recognized the vaccinal antigen.
Vaccines may fail for various reasons:
(1) MDA neutralizes the vaccine virus
This is the most common reason for vaccination failure. However, when the last vaccine dose is given at 14–16 weeks of age, MDA should have decreased to a low level, and active immunization will succeed in most puppies (>98%).
(2) The vaccine is poorly immunogenic
Poor immunogenicity may reflect a range of factors from the stage of vaccine manufacture to administration to the animal. For example, the virus strain, its passage history or production errors in the manufacture of a particular batch of product may be a cause of vaccine failure. Post-manufacture factors such as incorrect storage or transportation (interrupted cold chain) and handling (disinfectant use) of the vaccine in the veterinary practice, may result in inactivation of an MLV product.
(3) The animal is a poor responder (its immune system intrinsically fails to recognize the vaccinal antigens)
If an animal fails to develop an antibody response after repeated revaccination, it should be considered a non-responder. Because immunological non-responsiveness is genetically controlled in other species, certain breeds of dogs have been suspected to be poorresponders. It is believed (but unproven) that the high susceptibility to CPV-2 recognized in certain Rottweilers and Dobermans during the 1980s (regardless of their vaccination history) was due to a high prevalence of non-responders. In the USA today, these two breeds seem to have no greater numbers of non-responders to CPV-2 than other breeds, possibly because carriers of the genetic trait may have died from CPV-2 infection.Some dogs of these breeds may be low or non-responders to other antigens. For example, in the UK and Germany, the non-responder phenotype is prevalent amongst Rottweilers for CPV-2 and rabies virus as recent studies have shown this breed to have a higher proportion of animals failing to achieve the titre of rabies antibody required for pet travel.
Serological Testing to Determine the Duration of Immunity (DOI)
Most vaccinated dogs will have a persistence of serum antibody (against core vaccine antigens) for many years. Immunologically, this antibody reflects the function of a distinct population of long-lived plasma cells (memory effector B cells). Induction of immunological memory is the primary objective of vaccination. For core vaccines there is excellent correlation between the presence of antibody and protective immunity and there is long DOI for these products. This correlation does not exist for many of the noncore vaccines and the DOI related to these products necessitates more frequent revaccination intervals.
Antibody tests can be used to demonstrate the DOI after vaccination with core vaccines. It is known that dogs often maintain protective antibody to CDV, CPV-2, CAV-1, and CAV-2 for three or more years and numerous experimental studies support this observation. Therefore, when antibody is absent (irrespective of the serological test used) the dog should be revaccinated unless there is a medical basis for not so doing. Antibody determinations to other vaccine components are of limited or no value because of the short time period these antibodies persist (e.g. Leptospira products) or the lack of correlation between serum antibody and protection (e.g. Leptospira or canine parainfluenza). Important considerations in performing antibody tests are the cost and the time to obtain results.
The VGG recognizes that at present such serological testing has limited availability and might be relatively expensive. However, the principles of ‘evidence-based veterinary medicine’ would dictate that testing for antibody status (for either pups or adult dogs) is a better practice than simply administering a vaccine booster on the basis that this should be ‘safe and cost less’. In response to these needs, more rapid, cost-effective tests are being developed.
Passive Immunization
While vaccination (i.e. active immunization) dominates infectious disease prevention, passive immunization also has a venerable history, from the first anti-diphtheria serum to hyperimmune sera available for protecting human infants against anthrax, botulism, and scarlet fever, and adults against varicella-zoster, respiratory syncytial virus, hepatitis A and B, mumps, measles and rabies.
Although virus infections trigger both cellular and humoral immunity, it is mainly the antibody response that contributes to the reduction of viral load and recovery. In many virus infections, antibody levels are therefore taken as correlates of protection. During viraemia, pre-existing or injected antibodies directed against surface structures of virions latch on to the particles, neutralize their infectivity and prepare them for removal. Therapeutically, the serum or immunoglobulin preparations are injected subcutaneously
and quickly reach the circulation. Not unexpectedly, intravenous infusions of plasma (not serum) have been found to work as well but this is a more difficult practice that must be used with caution. In local infections, such as those initiated by the bite wound of a rabid carnivore, post-exposure antibody prophylaxis has also proven invaluable.
Bron: http://www.wsava.org/sites/default/files/VaccinationGuidelines2010.pdf
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